2. Gene
  3. Git1 - GIT ArfGAP 1 Gene

Git1 - GIT ArfGAP 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83709 | Gene type: protein coding

About Git1

Summary

Enables GTPase activator activity; identical protein binding activity; and small GTPase binding activity. A structural constituent of postsynaptic specialization. Involved in several processes, including cellular response to epidermal growth factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of signal transduction. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in several cellular components, including cytosol; endosome; and neuron projection. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]

Git1 Products(1)

mRNA Protein Name
NM_031814.2 NP_114002.1 ARF GTPase-activating protein GIT1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
9826657 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15212761 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12473661 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
12629171 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12629171 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12629171 RGD
enables small GTPase binding IDA
IDA: Inferred from direct assay
9826657 RGD
enables structural constituent of postsynaptic specialization IDA
IDA: Inferred from direct assay
25284783 RGD
enables structural constituent of postsynaptic specialization IMP
IMP: Inferred from mutant phenotype
25284783 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
18523162 RGD
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
17310244 RGD
acts upstream of or within immunological synapse formation IGI
IGI: Inferred from genetic interaction
17310244 RGD
involved in negative regulation of ARF protein signal transduction IDA
IDA: Inferred from direct assay
16439353 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
25284783 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
25284783 RGD
involved in positive regulation of receptor catabolic process IMP
IMP: Inferred from mutant phenotype
18523162 RGD
involved in regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9826657 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25284783 RGD
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25284783 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12629171 RGD
located in endosome IDA
IDA: Inferred from direct assay
18523162 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
12629171 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25284783 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12629171 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
12629171 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
25284783 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ARF GTPase-activating protein GIT1

ARF GAP GIT1

CAT-1

CAT1

G protein-coupled receptor kinase interacting ArfGAP 1

G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1)

G protein-coupled receptor kinase-interactor 1

GRK-interacting prote

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-RS05438 GIT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19605 Git1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26101 Git1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Git1 NCBI NCBI:28964