Nefl - neurofilament light chain Gene

Rattus norvegicus

Also known as Nfl; NF-L; NF68

Gene ID: 83613 | Gene type: protein coding

About Nefl

Summary

Enables Phospholipase binding activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; intermediate filament Cytoskeleton organization; and response to corticosterone. Located in growth cone and neurofilament. Colocalizes with neuron projection. Used to study congenital hypothyroidism. Biomarker of hypothyroidism; mental depression; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefl Products(1)

mRNA	Protein	Name
NM_031783.2	NP_113971.1	neurofilament light polypeptide

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipase binding	IPI IPI: Inferred from physical interaction	16819285	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16819285	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9388258	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	10439464	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	14620872	RGD
involved in intermediate filament polymerization or depolymerization	IDA IDA: Inferred from direct assay	10362553	RGD
involved in neurofilament bundle assembly	IDA IDA: Inferred from direct assay	7721944	RGD
involved in protein polymerization	IDA IDA: Inferred from direct assay	17157386	RGD
involved in response to acrylamide	IEP IEP: Inferred from expression pattern	17043767	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	17229084	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18157692	RGD
involved in response to sodium arsenite	IDA IDA: Inferred from direct assay	18674524	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	18001836	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	2108255	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	8737171	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12226091	RGD
located in neurofilament	IDA IDA: Inferred from direct assay	7721944	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurofilament light polypeptide

68 kDa neurofilament protein	68kDa neurofilament
neurofilament triplet L protein	neurofilament, light polypeptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09184	NEFL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17540	Nefl Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23998	Nefl Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nefl	NCBI	NCBI:4747
Mus musculus	Nefl	NCBI	NCBI:18039

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