Usf1 - upstream transcription factor 1 Gene

Rattus norvegicus

Gene ID: 83586 | Gene type: protein coding

About Usf1

Summary

Enables DNA binding activity; DNA-binding transcription factor activity; and identical protein binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in glucose metabolic process and positive regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Usf1 Products(1)

mRNA	Protein	Name
NM_031777.3	NP_113965.1	upstream stimulatory factor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12200434	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12200434	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17408383	RGD
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17408383	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	17408383	RGD
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	8576131	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	8576131	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17408383	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glucose metabolic process	IDA IDA: Inferred from direct assay	12200434	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15557322	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17408383	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12200434	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

upstream stimulatory factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15513	USF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19651	Usf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26144	Usf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Usf1	NCBI	NCBI:7391

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