2. Gene
  3. Tfam - transcription factor A, mitochondrial Gene

Tfam - transcription factor A, mitochondrial Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mttfa

Gene ID: 83474 | Gene type: protein coding

About Tfam

Summary

Enables heat shock protein binding activity and transcription coactivator binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and transcription initiation from mitochondrial promoter. Predicted to act upstream of or within mitochondrial respiratory chain complex assembly. Located in mitochondrion. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

Tfam Products(1)

mRNA Protein Name
NM_031326.2 NP_112616.2 transcription factor A, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
22003111 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
23297307 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
33310031 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor A, mitochondrial

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14407 TFAM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-172199 THX6 / Unkown
HY-RS17056 Tfam Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23500 Tfam Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfam NCBI NCBI:7019
Mus musculus Tfam NCBI NCBI:21780