2. Gene
  3. Mdh2 - malate dehydrogenase 2 Gene

Mdh2 - malate dehydrogenase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mor1

Gene ID: 81829 | Gene type: protein coding

About Mdh2

Summary

Enables L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity; and protein self-association. Involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrial matrix. Used to study brain ischemia; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mdh2 Products(1)

mRNA Protein Name
NM_031151.3 NP_112413.2 malate dehydrogenase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-malate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
12351438 RGD
enables L-malate dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
16737718 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
3580173 RGD
enables malate dehydrogenase activity IDA
IDA: Inferred from direct assay
1898089 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15809022 RGD
Biological Process GO Annotation Evidence Reference Source
involved in NADH metabolic process IDA
IDA: Inferred from direct assay
12351438 RGD
involved in malate metabolic process IDA
IDA: Inferred from direct assay
1898089 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
6409145 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

malate dehydrogenase, mitochondrial

malate dehydrogenase 2, NAD (mitochondrial)

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13671 LW6 98.47% Unkown
HY-147791 MDH1-IN-2 Inhibitor 98.70% Unkown
HY-RS08261 MDH2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16896 Mdh2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23338 Mdh2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdh2 NCBI NCBI:4191