PDPK1 - Pdpk1 3-phosphoinositide dependent protein kinase-1 Gene

Rattus norvegicus

Gene ID: 81745 | Gene type: protein coding

About PDPK1

Summary

Enables 3-phosphoinositide-dependent protein kinase activity; Insulin Receptor binding activity; and protein kinase binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; focal adhesion assembly; and negative regulation of neuron apoptotic process. Located in cytosol; perikaryon; and plasma membrane. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

PDPK1 Products(1)

mRNA	Protein	Name
NM_031081.2	NP_112343.2	3-phosphoinositide-dependent protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-phosphoinositide-dependent protein kinase activity	IDA IDA: Inferred from direct assay	14585963	RGD
enables insulin receptor binding	IDA IDA: Inferred from direct assay	16314505	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	14585963	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: Inferred from expression pattern	18971483	RGD
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	14585963	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18971483	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perikaryon	IDA IDA: Inferred from direct assay	18971483	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

3-phosphoinositide-dependent protein kinase 1

pkB kinase

protein kinase B kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12063	PHT-427		98.09%	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-RS10287	PDPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W719359	PHT-427-d4		/	Unkown
HY-RS17027	Pdpk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23470	Pdpk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PDPK1	NCBI	NCBI:5170

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