Musk - muscle associated receptor tyrosine kinase Gene

Rattus norvegicus

Also known as Nsk1

Gene ID: 81725 | Gene type: protein coding

About Musk

Summary

Enables protein kinase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of synaptic transmission; and sensory organ development. Located in cell projection; external side of plasma membrane; and neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Musk Products(1)

mRNA	Protein	Name
NM_031061.2	NP_112323.2	muscle, skeletal receptor tyrosine protein kinase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15604144	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16818610	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12220490	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cochlea development	IEP IEP: Inferred from expression pattern	18420419	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16870737	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	16870737	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	15604144	RGD
involved in neuromuscular junction development	IEP IEP: Inferred from expression pattern	7546737	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16870737	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	18436384	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18436384	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16870737	RGD
involved in positive regulation of synaptic assembly at neuromuscular junction	IMP IMP: Inferred from mutant phenotype	14749715	RGD
involved in positive regulation of synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	16870737	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16818610	RGD
involved in receptor clustering	IMP IMP: Inferred from mutant phenotype	16818610	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	9698449	RGD
involved in response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	16870737	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	9698449	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	16899069	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	16899069	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17011580	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	9698449	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

muscle, skeletal receptor tyrosine protein kinase

muscle specific kinase (neural fold/somite kinase 1)	muscle, skeletal, receptor tyrosine kinase
muscle-specific kinase receptor	muscle-specific tyrosine kinase receptor MuSK
muscle-specific tyrosine protein kinase receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-15590	AZ-23	Inhibitor	98.92%	Unkown
HY-P5438	Srctide	Substrate	99.93%	Unkown
HY-N2045	Musk ketone		99.41%	Unkown
HY-N3127	Orobol	Inhibitor	99.28%	Unkown
HY-116108	Musk tibetene	Ligand	/	Unkown
HY-RS08852	MUSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17455	Musk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23912	Musk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991115	Adimanebart		/	Unkown
HY-P991066	ARGX-119		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Musk	NCBI	NCBI:4593
Macaca fascicularis	Musk	NCBI	NCBI:102127677
Mus musculus	Musk	NCBI	NCBI:18198

Name
Email *

	Sorry, but the email address you supplied was invalid.