2. Gene
  3. Mlh1 - mutL homolog 1 Gene

Mlh1 - mutL homolog 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81685 | Gene type: protein coding

About Mlh1

Summary

Predicted to enable several functions, including ATP hydrolysis activity; chromatin binding activity; and guanine/thymine mispair binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in several processes, including response to hypoxia; response to toxic substance; and spermatogenesis. Located in synaptonemal complex. Used to study lung carcinoma. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system Cancer (multiple); lung cancer; mismatch repair Cancer syndrome; and sporadic breast Cancer. Orthologous to human MLH1 (mutL homolog 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlh1 Products(1)

mRNA Protein Name
NM_031053.2 NP_112315.2 DNA mismatch repair protein Mlh1
Protein Preferred Names Protein Names

DNA mismatch repair protein Mlh1

mismatch repair protein 1

mutL homolog 1, colon cancer, nonpolyposis type 2

mutL protein homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08489 MLH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19146 Mlh1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25637 Mlh1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlh1 NCBI NCBI:4292