MIF - Mif macrophage migration inhibitory factor Gene

Rattus norvegicus

Gene ID: 81683 | Gene type: protein coding

About MIF

Summary

Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of transport; response to steroid hormone; and response to vitamin. Located in cytoplasm; extracellular space; and nucleus. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Apr 2022]

MIF Products(1)

mRNA	Protein	Name
NM_031051.2	NP_112313.1	macrophage migration inhibitory factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15947686	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain renin-angiotensin system	IMP IMP: Inferred from mutant phenotype	17261648	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19799867	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	19462902	RGD
involved in drinking behavior	IMP IMP: Inferred from mutant phenotype	16809436	RGD
involved in hair follicle development	IEP IEP: Inferred from expression pattern	16232303	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	11086030	RGD
involved in positive regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	16455830	RGD
involved in positive regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	12456989	RGD
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	11086030	RGD
involved in positive regulation of immune response	IMP IMP: Inferred from mutant phenotype	10617911	RGD
involved in positive regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	16267117	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	18270460	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17324399	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17565848	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	15196698	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	12435855	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	14980085	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15886670	RGD
involved in response to menaquinone	IEP IEP: Inferred from expression pattern	15856362	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	17324399	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	10609875	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16571782	RGD
involved in skin development	IEP IEP: Inferred from expression pattern	16232303	RGD
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	15169922	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15947686	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

macrophage migration inhibitory factor

L-dopachrome isomerase	L-dopachrome tautomerase
glutathione-binding 13 kDa protein	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
phenylpyruvate tautomerase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17009	Iguratimod	Inhibitor	98.49%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105077A	Nemifitide diTFA		98.01%	Phase 2
HY-16692	ISO-1	Inhibitor	99.94%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99262	Imalumab	Inhibitor	98.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110063	4-IPP	Inhibitor	99.46%	Unkown
HY-110095	(±)-CPSI-1306	Antagonist	99.64%	Unkown
HY-147390	MIF098	Inhibitor	99.88%	Unkown
HY-110084	BTZO-1		99.69%	Unkown
HY-123814	4-CPPC	Inhibitor	99.64%	Unkown
HY-148117	MD13	Inhibitor	99.96%	Unkown
HY-130332	Mitomycin A	Inhibitor	97.30%	Unkown
HY-N10096	Epoxyazadiradione		99.21%	Unkown
HY-W019710	(E,E)-RGFP966	Inhibitor	99.31%	Unkown
HY-W164560	RDR 03785	Inhibitor	96.24%	Unkown
HY-107663A	MIF-1 TFA	Modulator	99.25%	Unkown
HY-115887	R110	Inhibitor	99.90%	Unkown
HY-D0039	3-Cyanoumbelliferone		≥98.0%	Unkown
HY-149308	MKA031	Inhibitor	98.69%	Unkown
HY-107663	MIF-1	Modulator	/	Unkown
HY-115888	MIF2-IN-1	Inhibitor	/	Unkown
HY-144190	MIF-IN-1	Inhibitor	/	Unkown
HY-144194	MIF-IN-2	Inhibitor	/	Unkown
HY-144195	MIF-IN-3	Inhibitor	/	Unkown
HY-144196	MIF-IN-4 hydrochloride	Inhibitor	/	Unkown
HY-146318	MIF-IN-5	Inhibitor	/	Unkown
HY-146319	MIF-IN-6	Inhibitor	/	Unkown
HY-155466	Boc-MIF-1-Am	Activator	/	Unkown
HY-P3087	Tyr-W-MIF-1	Modulator	/	Unkown
HY-RS08445	MIF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-173624	TE-11	Inhibitor	/	Unkown
HY-RS16522	Mif Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22953	Mif Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-U00271	Pareptide monohydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MIF	NCBI	NCBI:4282
Canis familiaris	MIF	NCBI	NCBI:595146
Macaca fascicularis	MIF	NCBI	NCBI:101867092
Mus musculus	MIF	NCBI	NCBI:17319

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