2. Gene
  3. ITPR2 - Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 Gene

ITPR2 - Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81678 | Gene type: protein coding

About ITPR2

Summary

Enables calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Located in axon; endoplasmic reticulum; and myelin sheath. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

ITPR2 Products(1)

mRNA Protein Name
NM_031046.4 NP_112308.2 inositol 1,4,5-trisphosphate receptor type 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
10969001 RGD
enables inositol 1,4,5 trisphosphate binding IDA
IDA: Inferred from direct assay
10969001 RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: Inferred from direct assay
10620513 RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
23166348 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23884412 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
17285299 RGD
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
23166348 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
17091480 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10969001 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
16014380 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol 1,4,5-trisphosphate receptor type 2

IP3 receptor

IP3R 2

inositol 1,4,5-triphosphate receptor 2

inositol 1,4,5-triphosphate receptor, type 2

inositol triphosphate receptor type 2

insP3R2

type 2 InsP3 receptor

type 2 inositol 1,4,5-trisphosphate receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06992 ITPR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20971 Itpr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27488 Itpr2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ITPR2 NCBI NCBI:3709