Gnaq - G protein subunit alpha q Gene

Rattus norvegicus

Also known as Galphaq

Gene ID: 81666 | Gene type: protein coding

About Gnaq

Summary

Enables alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including activation of Phospholipase C activity; negative regulation of potassium ion transport; and positive regulation of smooth muscle cell proliferation. Located in caveola; cytosol; and synapse. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q). [provided by Alliance of Genome Resources, Apr 2022]

Gnaq Products(1)

mRNA	Protein	Name
NM_031036.3	NP_112298.2	guanine nucleotide-binding protein G(q) subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alkylglycerophosphoethanolamine phosphodiesterase activity	IDA IDA: Inferred from direct assay	21812758	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12509430	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	20548297	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16466740	RGD
involved in negative regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	9614229	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9677408	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	16730745	RGD
part of heterotrimeric G-protein complex	IDA IDA: Inferred from direct assay	21812758	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	17144906	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(q) subunit alpha

guanine nucleotide binding protein (G protein), q polypeptide	guanine nucleotide binding protein alpha q subunit
guanine nucleotide binding protein, alpha q polypeptide	guanine nucleotide regulatory protein G alpha q
guanine nucleotide-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05539	GNAQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22188	Gnaq Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28710	Gnaq Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnaq	NCBI	NCBI:2776

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