Dpyd - dihydropyrimidine dehydrogenase Gene

Rattus norvegicus

Gene ID: 81656 | Gene type: protein coding

About Dpyd

Summary

Enables several functions, including nucleotide binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including pyrimidine nucleobase metabolic process; response to glucocorticoid; and response to nutrient. Located in cytosol. Used to study colorectal Cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic Cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Dpyd Products(1)

mRNA	Protein	Name
NM_031027.2	NP_112289.2	dihydropyrimidine dehydrogenase [NADP(+)]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables FAD binding	IDA IDA: Inferred from direct assay	7451435	RGD
enables NADP binding	IDA IDA: Inferred from direct assay	7626590	RGD
enables dihydropyrimidine dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	1544906	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	7451435	RGD
enables iron ion binding	IDA IDA: Inferred from direct assay	7451435	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8373446	RGD
enables uracil binding	IDA IDA: Inferred from direct assay	7626590	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IDA IDA: Inferred from direct assay	3202908	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19628084	RGD
involved in pyrimidine nucleobase catabolic process	IDA IDA: Inferred from direct assay	1629785	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	9819714	RGD
involved in response to nutrient	IDA IDA: Inferred from direct assay	8252488	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	9893640	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	8161345	RGD
involved in uracil metabolic process	IDA IDA: Inferred from direct assay	7626590	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	9348115	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dihydropyrimidine dehydrogenase [NADP(+)]

DHPDHase	DPD
dihydrothymine dehydrogenase	dihydrouracil dehydrogenase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17469	Gimeracil	Inhibitor	99.72%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03979	DPYD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W777340	Gimeracil-13C3		/	Unkown
HY-17469S	Gimeracil-13C3,15N		/	Unkown
HY-RS21328	Dpyd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27847	Dpyd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dpyd	NCBI	NCBI:1806

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