Creb1 - cAMP responsive element binding protein 1 Gene

Rattus norvegicus

Also known as Creb

Gene ID: 81646 | Gene type: protein coding

About Creb1

Summary

Enables several functions, including HSP70 protein binding activity; Arrestin family protein binding activity; and Histone Acetyltransferase binding activity. Involved in several processes, including cellular response to growth factor stimulus; learning or memory; and regulation of gene expression. Located in several cellular components, including axon; chromatin; and mitochondrial matrix. Part of transcription regulator complex. Used to study transient cerebral ischemia. Biomarker of Huntington's disease; brain ischemia; and sciatic neuropathy. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Creb1 Products(2)

mRNA	Protein	Name
NM_031017.2	NP_112279.1	cyclic AMP-responsive element-binding protein 1 isoform B
NM_134443.2	NP_604392.2	cyclic AMP-responsive element-binding protein 1 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	12697699	RGD
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12409294	RGD
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	16207717	RGD
enables arrestin family protein binding	IPI IPI: Inferred from physical interaction	21223624	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	12697699	RGD
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	22357921	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19196971	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12697699	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21367864	RGD
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	16382163	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	9413984	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell differentiation	IMP IMP: Inferred from mutant phenotype	31678682	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	16382163	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	23865718	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	18193038	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	21505978	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	21308733	RGD
involved in chemotaxis to arachidonate	IMP IMP: Inferred from mutant phenotype	16382163	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	21367864	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	16687181	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30566056	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21816899	RGD
involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP IMP: Inferred from mutant phenotype	16891311	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24189100	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16000619	RGD
involved in positive regulation of membrane depolarization	IMP IMP: Inferred from mutant phenotype	16641242	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12409294	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16891311	RGD
involved in positive regulation of transforming growth factor beta3 production	IMP IMP: Inferred from mutant phenotype	16891311	RGD
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	12939230	RGD
involved in regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	19285017	RGD
involved in regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	19365572	RGD
involved in response to L-glutamate	IEP IEP: Inferred from expression pattern	19365572	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	25031400	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	27664298	RGD
involved in response to dehydroepiandrosterone	IEP IEP: Inferred from expression pattern	22523357	RGD
involved in response to erythropoietin	IDA IDA: Inferred from direct assay	17368520	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	9581644	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18322102	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	22523357	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	24084215	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	19324071	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	22952905	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	21223624	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12697699	RGD
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16891311	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	25031400	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	18193038	RGD
located in chromatin	IDA IDA: Inferred from direct assay	15632413	RGD
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	16207717	RGD
located in nucleus	IDA IDA: Inferred from direct assay	19033670	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15632413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 1

CREB-1	Y protein
cAMP response element binding protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03148	CREB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P4497	Prolylserine		/	Unkown
HY-RS18270	Creb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24748	Creb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Creb1	NCBI	NCBI:1385

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