2. Gene
  3. Acta2 - actin alpha 2, smooth muscle Gene

Acta2 - actin alpha 2, smooth muscle Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81633 | Gene type: protein coding

About Acta2

Summary

Predicted to enable protein kinase binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of cellular component movement; and positive regulation of hepatic stellate cell activation. Located in cytoplasm and stress fiber. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Apr 2022]

Acta2 Products(1)

mRNA Protein Name
NM_031004.2 NP_112266.1 actin, aortic smooth muscle
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
17043753 RGD
involved in juxtaglomerular apparatus development IEP
IEP: Inferred from expression pattern
30645697 RGD
involved in muscle contraction IDA
IDA: Inferred from direct assay
11953441 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
24204762 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
24204762 RGD
involved in positive regulation of hepatic stellate cell contraction IMP
IMP: Inferred from mutant phenotype
24204762 RGD
involved in positive regulation of hepatic stellate cell migration IMP
IMP: Inferred from mutant phenotype
24204762 RGD
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
8616889 RGD
located in basement membrane IDA
IDA: Inferred from direct assay
30476341 RGD
located in stress fiber IDA
IDA: Inferred from direct assay
24204762 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin, aortic smooth muscle

actin, alpha 2, smooth muscle, aorta

alpha-actin-2

smooth muscle alpha-actin

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00214 ACTA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19169 Acta2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22375 Acta1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25658 Acta2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acta2 NCBI NCBI:59