Abat - 4-aminobutyrate aminotransferase Gene

Rattus norvegicus

Also known as Gabat; beta-AlaAT

Gene ID: 81632 | Gene type: protein coding

About Abat

Summary

Enables 4-aminobutyrate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix and neuron projection. Used to study several diseases, including Huntington's disease; epilepsy (multiple); heroin dependence; ischemia; and mental depression. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]

Abat Products(1)

mRNA	Protein	Name
NM_031003.2	NP_112265.1	4-aminobutyrate aminotransferase, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 4-aminobutyrate:2-oxoglutarate transaminase activity	IDA IDA: Inferred from direct assay	10447691	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebellum development	IEP IEP: Inferred from expression pattern	7182074	RGD
involved in copulation	IMP IMP: Inferred from mutant phenotype	8117236	RGD
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	8788866	RGD
involved in gamma-aminobutyric acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	19540876	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	7945972	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	8336820	RGD
involved in negative regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	590329	RGD
involved in negative regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	7722510	RGD
involved in positive regulation of aspartate secretion	IMP IMP: Inferred from mutant phenotype	2342602	RGD
involved in positive regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11239920	RGD
involved in positive regulation of heat generation	IMP IMP: Inferred from mutant phenotype	20878340	RGD
involved in positive regulation of inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	11495935	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	20695849	RGD
involved in positive regulation of prolactin secretion	IMP IMP: Inferred from mutant phenotype	4043235	RGD
involved in positive regulation of uterine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	12742000	RGD
involved in response to cocaine	IMP IMP: Inferred from mutant phenotype	12373739	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	7710740	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	10727784	RGD
involved in response to iron ion	IDA IDA: Inferred from direct assay	9719948	RGD
involved in response to nicotine	IMP IMP: Inferred from mutant phenotype	10025686	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	7931216	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	3132542	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

4-aminobutyrate aminotransferase, mitochondrial

(S)-3-amino-2-methylpropionate transaminase	GABA aminotransferase
GABA transaminase	GABA-AT
GABA-T	L-AIBAT
beta-AlaAT I	gamma-amino-N-butyrate transaminase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00036	ABAT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18027	Abat Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24500	Abat Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abat	NCBI	NCBI:18

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