2. Gene
  3. LIG1 - Lig1 DNA ligase 1 Gene

LIG1 - Lig1 DNA ligase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81513 | Gene type: protein coding

About LIG1

Summary

Enables DNA Ligase activity. Involved in DNA repair. Located in nucleus. Used to study epilepsy with generalized tonic-clonic seizures. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

LIG1 Products(1)

mRNA Protein Name
NM_001024268.3 NP_001019439.1 DNA ligase 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA ligase activity IDA
IDA: Inferred from direct assay
1730240 RGD
Biological Process GO Annotation Evidence Reference Source
involved in DNA repair IDA
IDA: Inferred from direct assay
1730240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA ligase 1

DNA ligase (ATP) 1

DNA ligase I

ligase I, DNA, ATP-dependent

polydeoxyribonucleotide synthase [ATP] 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15587 L82 Inhibitor 98.89% Unkown
HY-161152 DNA relaxation-IN-1 Inhibitor 99.37% Unkown
HY-W004883 3-Amino-4,6-dimethylpyridine Inhibitor 99.87% Unkown
HY-RS07642 LIG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07787 LRIG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18139 Lig1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19215 Lrig1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24614 Lig1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LIG1 NCBI NCBI:3978
Macaca fascicularis LIG1 NCBI NCBI:101864859