Tbl1xr1 - transducin (beta)-like 1X-linked receptor 1 Gene

Mus musculus

Also known as C21; DC42; Ira1; TBLR1; 8030499H02Rik; A630076E03Rik; C230089I12Rik

Gene ID: 81004 | Gene type: protein coding

About Tbl1xr1

Summary

Enables transcription cis-regulatory region binding activity and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blastocyst hatching; fat pad development; and white fat cell differentiation. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Is expressed in early conceptus; secondary oocyte; and thymus primordium. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 41. Orthologous to human TBL1XR1 (TBL1X receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbl1xr1 Products(1)

mRNA	Protein	Name
NM_030732.3	NP_109657.2	F-box-like/WD repeat-containing protein TBL1XR1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14980219	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14980219	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16127449	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	14980219	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within blastocyst hatching	IMP IMP: Inferred from mutant phenotype	27869233	MGI
acts upstream of or within fat pad development	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within lipid catabolic process	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14980219	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16127449	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	14980219	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within regulation of triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	23499424	MGI
acts upstream of or within white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23499424	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

F-box-like/WD repeat-containing protein TBL1XR1

F-box-like/WD repeat protein TBL1XR1	TBL1-related protein 1
nuclear receptor corepressor/HDAC3 complex subunit TBLR1	transducin beta-like 1X-related protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14262	TBL1XR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20223	Tbl1xr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26730	Tbl1xr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbl1xr1	NCBI	NCBI:79718

Name
Email *

	Sorry, but the email address you supplied was invalid.