1. Gene
  2. Aco2 - aconitase 2 Gene

Aco2 - aconitase 2 Gene

Rattus norvegicus
Gene ID: 79250 | Gene type: protein coding

About Aco2

Summary

Enables 3 iron, 4 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and aconitate hydratase activity. Involved in several processes, including response to isolation stress; tricarboxylic acid cycle; and tricarboxylic acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Apr 2022]

Aco2 Products(1)

mRNA Protein Name
NM_024398.2 NP_077374.2 aconitate hydratase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 3 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
14674759 RGD
enables 4 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
14674759 RGD
enables aconitate hydratase activity IDA
IDA: Inferred from direct assay
9712727 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15840721 RGD
Biological Process GO Annotation Evidence Reference Source
involved in citrate metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in isocitrate metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
755797 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
19616040 RGD
involved in tricarboxylic acid cycle IDA
IDA: Inferred from direct assay
9712727 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aconitate hydratase, mitochondrial

aconitase 2, mitochondrial

citrate hydro-lyase

mitochondrial aconitase (nuclear aco2 gene)

Orthologs Information

Species Symbol Source ID
Homo sapiens Aco2 NCBI NCBI:50
Mus musculus Aco2 NCBI NCBI:11429