2. Gene
  3. Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as MFP-2; MPF-2

Gene ID: 79244 | Gene type: protein coding

About Hsd17b4

Summary

Enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydratase activity; and identical protein binding activity. Involved in several processes, including aging; cellular response to organic cyclic compound; and response to steroid hormone. Located in peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b4 Products(1)

mRNA Protein Name
NM_024392.2 NP_077368.2 peroxisomal multifunctional enzyme type 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
9084892 RGD
enables 3-hydroxyacyl-CoA dehydratase activity IDA
IDA: Inferred from direct assay
8902630 RGD
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
12225901 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
20566640 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12706301 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16038268 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
25603467 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9209713 RGD
Cellular Component GO Annotation Evidence Reference Source
located in peroxisome IDA
IDA: Inferred from direct assay
14561759 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxisomal multifunctional enzyme type 2

17-beta-HSD 4

17-beta-hydroxysteroid dehydrogenase 4

D-bifunctional protein

DBP

MFE-2

multifunctional protein 2

peroxisomal multifunctional enzyme type II

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120897 NS-3-008 hydrochloride Inhibitor 99.65% Unkown
HY-RS06397 HSD17B4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20632 Hsd17b4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27141 Hsd17b4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b4 NCBI NCBI:3295