Slc6a1 - solute carrier family 6 member 1 Gene

Rattus norvegicus

Also known as Gat1; Gabt1

Gene ID: 79212 | Gene type: protein coding

About Slc6a1

Summary

Enables gamma-aminobutyric acid:sodium symporter activity and identical protein binding activity. Involved in several processes, including gamma-aminobutyric acid import; negative regulation of GABAergic synaptic transmission; and positive regulation of gamma-aminobutyric acid secretion. Located in cell surface; neuron projection; and plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study brain ischemia. Biomarker of cerebral infarction; epilepsy; temporal lobe epilepsy; and withdrawal disorder. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a1 Products(1)

mRNA	Protein	Name
NM_024371.3	NP_077347.1	sodium- and chloride-dependent GABA transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IDA IDA: Inferred from direct assay	1975955	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16314925	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11017172	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in gamma-aminobutyric acid import	IDA IDA: Inferred from direct assay	16378241	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	12110474	RGD
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	17317750	RGD
involved in neurotransmitter reuptake	IDA IDA: Inferred from direct assay	1975955	RGD
involved in neurotransmitter reuptake	IMP IMP: Inferred from mutant phenotype	1975955	RGD
involved in positive regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	14500747	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	15778221	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	12832547	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15664431	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	15149801	RGD
involved in response to methamphetamine hydrochloride	IEP IEP: Inferred from expression pattern	30275762	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17408599	RGD
involved in response to purine-containing compound	IMP IMP: Inferred from mutant phenotype	16730753	RGD
involved in response to sucrose	IEP IEP: Inferred from expression pattern	15778221	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	14500747	RGD
involved in response to toxic substance	IMP IMP: Inferred from mutant phenotype	14643747	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	24368619	RGD
located in cell surface	IDA IDA: Inferred from direct assay	14500747	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	24368619	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24368619	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium- and chloride-dependent GABA transporter 1

GABA transporter protein	GAT-1
solute carrier family 6 (neurotransmitter transporter), member 1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13296	SLC6A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21939	Slc6a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28456	Slc6a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a1	NCBI	NCBI:6529

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