2. Gene
  3. Cfi - complement factor I Gene

Cfi - complement factor I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as FI

Gene ID: 79126 | Gene type: protein coding

About Cfi

Summary

Predicted to enable metal ion binding activity; scavenger receptor activity; and serine-type endopeptidase activity. Involved in cellular response to interleukin-6. Located in extracellular space and nucleus. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I). [provided by Alliance of Genome Resources, Apr 2022]

Cfi Products(1)

mRNA Protein Name
NM_024157.1 NP_077071.1 complement factor I precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
11530941 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
11530941 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor I

C3B/C4B inactivator

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12300 Ocifisertib 99.78% Phase 2
HY-12300B Ocifisertib fumarate Inhibitor 99.27% Phase 2
HY-101340 Luvixasertib Inhibitor 99.77% Phase 1
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101340A Luvixasertib hydrochloride Inhibitor 99.13% Unkown
HY-132135 (1E)-CFI-400437 dihydrochloride Inhibitor 98.08% Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123675 CFI-400936 Inhibitor / Unkown
HY-RS02567 CFI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-12300A Ocifisertib hydrochloride / Unkown
HY-RS20677 Cfi Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27188 Cfi Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfi NCBI NCBI:3426
Mus musculus Cfi NCBI NCBI:12630