Prkaa2 - protein kinase AMP-activated catalytic subunit alpha 2 Gene

Rattus norvegicus

Also known as Ampk; Ampka2

Gene ID: 78975 | Gene type: protein coding

About Prkaa2

Summary

Enables AMP-activated protein kinase activity; ATP binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including energy homeostasis; fatty acid homeostasis; and positive regulation of glycolytic process. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa2 Products(1)

mRNA	Protein	Name
NM_023991.1	NP_076481.1	5'-AMP-activated protein kinase catalytic subunit alpha-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	11069105	RGD
enables AMP-activated protein kinase activity	IMP IMP: Inferred from mutant phenotype	8955377	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	16648175	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11069105	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	12065578	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8955377	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	14511394	RGD
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	15695819	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	25788287	RGD
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	25788287	RGD
involved in energy homeostasis	IDA IDA: Inferred from direct assay	11724780	RGD
involved in fatty acid homeostasis	IDA IDA: Inferred from direct assay	11724780	RGD
involved in positive regulation of glycolytic process	IDA IDA: Inferred from direct assay	11069105	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8955377	RGD
involved in regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	12065578	RGD
involved in response to activity	IDA IDA: Inferred from direct assay	17253964	RGD
involved in response to caffeine	IDA IDA: Inferred from direct assay	19608206	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18256313	RGD
located in axon	IMP IMP: Inferred from mutant phenotype	25788287	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	18256313	RGD
located in dendrite	IMP IMP: Inferred from mutant phenotype	25788287	RGD
located in neuronal cell body	IMP IMP: Inferred from mutant phenotype	25788287	RGD
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	16648175	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	14511394	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

5'-AMP-activated protein kinase catalytic subunit alpha-2

ACACA kinase	AMP-activated protein kinase
AMPK alpha-2 chain	AMPK subunit alpha-2
HMGCR kinase	acetyl-CoA carboxylase kinase
hydroxymethylglutaryl-CoA reductase kinase	protein kinase, AMP-activated, alpha 2 catalytic subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11101	PRKAA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21177	Prkaa2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27694	Prkaa2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkaa2	NCBI	NCBI:5563

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