Srebf1 - sterol regulatory element binding transcription factor 1 Gene

Rattus norvegicus

Also known as ADD1; ADD-1; Srebp1; SREBP-1; SREBP-1c

Gene ID: 78968 | Gene type: protein coding

About Srebf1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including response to peptide hormone; response to progesterone; and response to retinoic acid. Located in nucleus. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Srebf1 Products(2)

mRNA	Protein	Name
NM_001276707.1	NP_001263636.1	sterol regulatory element-binding protein 1 isoform 1 precursor
NM_001276708.1	NP_001263637.1	sterol regulatory element-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16407292	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16407292	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	19371623	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19158095	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9786926	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	19332540	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	10207099	RGD
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	16407292	RGD
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	18071061	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	12896875	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10207099	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16407292	RGD
involved in regulation of lipid storage	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	10207099	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	16222032	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	19357831	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	11934685	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	10207099	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	12421847	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	26394137	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19371623	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18801905	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	11278421	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	9121491	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17526932	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	19158095	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sterol regulatory element-binding protein 1

adipocyte determination- and differentiation-dependent factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13757	SREBF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17721	Srebf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24186	Srebf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29460	SREBF1 Pig Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srebf1	NCBI	NCBI:6720

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