Rictor - RPTOR independent companion of MTOR, complex 2 Gene

Mus musculus

Also known as AVO3; 4921505C17Rik; 6030405M08Rik; D530039E11Rik

Gene ID: 78757 | Gene type: protein coding

About Rictor

Summary

Enables ribosome binding activity. Involved in embryo development; regulation of protein kinase B signaling; and regulation of protein phosphorylation. Acts upstream of or within several processes, including positive regulation of actin filament polymerization; regulation of GTPase activity; and regulation of protein phosphorylation. Part of TORC2 complex. Is expressed in early conceptus and oocyte. Orthologous to human RICTOR (RPTOR independent companion of mTOR complex 2). [provided by Alliance of Genome Resources, Apr 2022]

Rictor Products(1)

mRNA	Protein	Name
NM_030168.3	NP_084444.3	rapamycin-insensitive companion of mTOR

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18566586	MGI
enables ribosome binding	IDA IDA: Inferred from direct assay	21045808	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in embryo development ending in birth or egg hatching	IMP IMP: Inferred from mutant phenotype	16962829	MGI
acts upstream of or within positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	15467718	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	15467718	MGI
acts upstream of or within regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15467718	MGI
acts upstream of or within regulation of establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	24740015	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24740015	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24740015	MGI
acts upstream of or within regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	24740015	MGI
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16962829	MGI
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23092880	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of TORC2 complex	IDA IDA: Inferred from direct assay	16962653	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rapamycin-insensitive companion of mTOR

AVO3 homolog	mAVO3
protein pianissimo

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19307	SB-273005		99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122022	JR-AB2-011	Inhibitor	98.15%	Unkown
HY-RS11969	RICTOR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17350	Rictor Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23804	Rictor Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rictor	NCBI	NCBI:253260

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