2. Gene
  3. Lbh - limb-bud and heart Gene

Lbh - limb-bud and heart Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1810009F10Rik; 6720416L16Rik

Gene ID: 77889 | Gene type: protein coding

About Lbh

Summary

Involved in several processes, including negative regulation of intracellular Estrogen receptor signaling pathway; positive regulation of mammary stem cell proliferation; and positive regulation of somatic stem cell division. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including gut; heart; limb bud; mesendoderm; and nervous system. Orthologous to human LBH (LBH regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Lbh Products(1)

mRNA Protein Name
NM_029999.4 NP_084275.3 protein LBH
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in mammary gland development IMP
IMP: Inferred from mutant phenotype
25655704 MGI
involved in mammary gland epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
25655704 MGI
involved in negative regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25655704 MGI
involved in negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
25655704 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11336496 MGI
involved in positive regulation of mammary stem cell proliferation IMP
IMP: Inferred from mutant phenotype
25655704 MGI
involved in positive regulation of somatic stem cell division IMP
IMP: Inferred from mutant phenotype
25655704 MGI
involved in positive regulation of somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
25655704 MGI
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25655704 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11336496 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein LBH

limb bud and heart-expressed protein

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10224 Panobinostat 99.37% Yes
HY-10224A Panobinostat lactate 98.67% Yes
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10224R Panobinostat (Standard) / Unkown
HY-10224S Panobinostat-d4 / Unkown
HY-10224S1 Panobinostat-d4 hydrochloride / Unkown
HY-RS07542 LBH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20682 Lbh Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lbh NCBI NCBI:81606