2. Gene
  3. Kdm8 - lysine (K)-specific demethylase 8 Gene

Kdm8 - lysine (K)-specific demethylase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jmjd5; 3110005O21Rik

Gene ID: 77035 | Gene type: protein coding

About Kdm8

Summary

Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; methylated histone binding activity; and peptidase activity. Involved in circadian regulation of gene expression and protein destabilization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; nervous system; and trachea. Orthologous to human KDM8 (lysine demethylase 8). [provided by Alliance of Genome Resources, Apr 2022]

Kdm8 Products(1)

mRNA Protein Name
NM_029842.5 NP_084118.1 bifunctional peptidase and arginyl-hydroxylase JMJD5
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
26334721 MGI
enables p53 binding IDA
IDA: Inferred from direct assay
26334721 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
30500822 MGI
Biological Process GO Annotation Evidence Reference Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
30500822 MGI
acts upstream of or within fibroblast proliferation IGI
IGI: Inferred from genetic interaction
26334721 MGI
acts upstream of or within fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
26334721 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
26334721 MGI
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
30500822 MGI
acts upstream of or within regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
26334721 MGI
acts upstream of or within regulation of signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
26334721 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional peptidase and arginyl-hydroxylase JMJD5

L-arginine (3R)-hydroxylase KDM8

arginyl C3-hydroxylase KDM8

jmjC domain-containing protein 5

jumonji C domain-containing protein 5

jumonji domain containing 5

jumonji domain-containing protein 5

lysine-specific demethylase 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07225 KDM8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20759 Kdm8 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27272 Kdm8 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm8 NCBI NCBI:79831