Gper1 - G protein-coupled estrogen receptor 1 Gene

Mus musculus

Also known as Gper; Ceprl; FEG-1; Gpr30; CMKRL2; GPCR-Br; 6330420K13Rik

Gene ID: 76854 | Gene type: protein coding

About Gper1

Summary

Enables Estrogen receptor activity. Involved in several processes, including cellular chemical homeostasis; positive regulation of cell communication; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm; hippocampal mossy fiber to CA3 synapse; and plasma membrane. Is expressed in embryo; metanephros; and pituitary gland. Orthologous to human GPER1 (G protein-coupled Estrogen receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gper1 Products(1)

mRNA	Protein	Name
NM_029771.3	NP_084047.2	G-protein coupled estrogen receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear estrogen receptor activity	IDA IDA: Inferred from direct assay	23545157	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	21149639	MGI
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	21149639	MGI
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	21673097	MGI
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	29421611	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	29421611	MGI
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	23871778	MGI
involved in negative regulation of lipid biosynthetic process	IDA IDA: Inferred from direct assay	23871778	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21673097	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	23871778	MGI
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	21673097	MGI
involved in positive regulation of epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	21673097	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	21673097	MGI
involved in positive regulation of neurogenesis	IDA IDA: Inferred from direct assay	23545157	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	21673097	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23545157	MGI
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	23871778	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21149639	MGI
is active in hippocampal mossy fiber to CA3 synapse	EXP EXP: Inferred from Experiment	29421611	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	29421611	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21149639	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

G-protein coupled estrogen receptor 1

G-protein coupled receptor 30	chemoattractant receptor-like 2
constitutively expressed peptide-like receptor like	mER
membrane estrogen receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05636	GPER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18518	Gper1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25000	Gper1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gper1	NCBI	NCBI:2852

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