Tbx18 - T-box18 Gene

Mus musculus

Also known as 2810012F10Rik; 2810404D13Rik

Gene ID: 76365 | Gene type: protein coding

About Tbx18

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; anterior/posterior pattern specification; and positive regulation of cell population proliferation. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including body cavity or lining; cardiovascular system; embryo mesenchyme; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]

Tbx18 Products(1)

mRNA	Protein	Name
NM_023814.4	NP_076303.3	T-box transcription factor TBX18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17584735	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17584735	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17584735	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17584735	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17584735	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	19096026	MGI
acts upstream of or within anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	15155583	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	18353863	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	18353863	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of mesenchymal cell proliferation involved in ureter development	IGI IGI: Inferred from genetic interaction	20110314	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of myoblast proliferation	IGI IGI: Inferred from genetic interaction	20110314	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17584735	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17584735	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17584735	MGI
involved in neural plate anterior/posterior regionalization	IMP IMP: Inferred from mutant phenotype	17584735	MGI
acts upstream of or within positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18353863	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation involved in ureter development	IGI IGI: Inferred from genetic interaction	20110314	MGI
acts upstream of or within positive regulation of myoblast proliferation	IGI IGI: Inferred from genetic interaction	20110314	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	18353863	MGI
acts upstream of or within sinoatrial node development	IMP IMP: Inferred from mutant phenotype	19096026	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	15155583	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18353863	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16511601	MGI
acts upstream of or within ureter development	IGI IGI: Inferred from genetic interaction	20881014	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription repressor complex	IDA IDA: Inferred from direct assay	17584735	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17584735	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-box transcription factor TBX18

T-box protein 18

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14273	TBX18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22847	Tbx18 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx18	NCBI	NCBI:9096

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