Slc38a3 - solute carrier family 38, member 3 Gene

Mus musculus

Also known as Sn1; Nat1; mNAT; Snat3; D9Ucla2; Slc38-3; 0610012J02Rik

Gene ID: 76257 | Gene type: protein coding

About Slc38a3

Summary

Enables L-glutamine transmembrane transporter activity and L-histidine transmembrane transporter activity. Acts upstream of or within amino acid transport; cellular response to potassium ion starvation; and positive regulation of transcription from RNA polymerase II promoter in response to acidic pH. Located in apical plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system; metanephros; pancreas; pericardium; and retina. Orthologous to human SLC38A3 (solute carrier family 38 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc38a3 Products(3)

mRNA	Protein	Name
NM_001199217.1	NP_001186146.1	sodium-coupled neutral amino acid transporter 3
NM_001199218.1	NP_001186147.1	sodium-coupled neutral amino acid transporter 3
NM_023805.3	NP_076294.2	sodium-coupled neutral amino acid transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-asparagine, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	16249471	MGI
enables L-glutamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10716701	MGI
enables L-glutamine, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	16249471	MGI
enables L-histidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10716701	MGI
enables L-histidine, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	15899884	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamine import across plasma membrane	IDA IDA: Inferred from direct assay	18689705	MGI
involved in L-histidine import across plasma membrane	IDA IDA: Inferred from direct assay	15899884	MGI
acts upstream of or within cellular response to potassium ion starvation	IDA IDA: Inferred from direct assay	19458124	MGI
involved in glutamine secretion	IDA IDA: Inferred from direct assay	29561757	MGI
acts upstream of or within glutamine transport	IDA IDA: Inferred from direct assay	10716701	MGI
acts upstream of or within histidine transport	IDA IDA: Inferred from direct assay	10716701	MGI
involved in intracellular amino acid homeostasis	IMP IMP: Inferred from mutant phenotype	26490457	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19458124	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	32046769	MGI
located in membrane	IDA IDA: Inferred from direct assay	19458124	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10716701	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium-coupled neutral amino acid transporter 3

N system amino acids transporter NAT-1	N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3	system N amino acid transporter 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13221	SLC38A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22043	Slc38a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc38a3	NCBI	NCBI:10991

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