2. Gene
  3. Nme5 - NME/NM23 family member 5 Gene

Nme5 - NME/NM23 family member 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nm23-M5; 1700019D05Rik

Gene ID: 75533 | Gene type: protein coding

About Nme5

Summary

Predicted to enable nucleoside diphosphate kinase activity. Involved in spermatid development. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and ventricular system development. Located in sperm flagellum. Is expressed in lung epithelium; nasal cavity respiratory epithelium; and nasopharynx epithelium. Used to study hydrocephalus. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Nme5 Products(1)

mRNA Protein Name
NM_080637.4 NP_542368.2 nucleoside diphosphate kinase homolog 5
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
21746835 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
21746835 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
21746835 MGI
acts upstream of or within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12788088 MGI
involved in spermatid development IDA
IDA: Inferred from direct assay
12788088 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
19303412 MGI
acts upstream of or within ventricular system development IMP
IMP: Inferred from mutant phenotype
21746835 MGI
Cellular Component GO Annotation Evidence Reference Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
32203505 MGI
part of radial spoke IDA
IDA: Inferred from direct assay
36417862 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
19303412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleoside diphosphate kinase homolog 5

NDK-H 5

NDP kinase homolog 5

expressed in non-metastatic cells 5

non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

rsph23

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09376 NME5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22261 Nme5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nme5 NCBI NCBI:8382