Tdrd9 - tudor domain containing 9 Gene

Mus musculus

Also known as 4930441E05Rik

Gene ID: 74691 | Gene type: protein coding

About Tdrd9

Summary

Predicted to enable RNA binding activity. Involved in fertilization; gamete generation; and piRNA metabolic process. Acts upstream of or within negative regulation of transposition. Located in nucleus and piP-body. Is expressed in germ cell of testis. Human ortholog(s) of this gene implicated in spermatogenic failure 30. Orthologous to human TDRD9 (tudor domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]

Tdrd9 Products(2)

mRNA	Protein	Name
NM_029056.1	NP_083332.1	ATP-dependent RNA helicase TDRD9
NM_029056.1	NP_083332.1	ATP-dependent RNA helicase TDRD9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	28633017	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20059948	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fertilization	IMP IMP: Inferred from mutant phenotype	20059948	MGI
involved in male meiosis I	IMP IMP: Inferred from mutant phenotype	28633017	MGI
involved in male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	20059948	MGI
involved in piRNA processing	IMP IMP: Inferred from mutant phenotype	20059948	MGI
involved in piRNA-mediated retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	28633017	MGI
acts upstream of or within retrotransposon silencing	IMP IMP: Inferred from mutant phenotype	27473657	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IMP IMP: Inferred from mutant phenotype	20059948	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	20059948	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20059948	MGI
located in piP-body	IDA IDA: Inferred from direct assay	20011505	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase TDRD9

putative ATP-dependent RNA helicase TDRD9

tudor domain-containing protein 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14339	TDRD9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22852	Tdrd9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tdrd9	NCBI	NCBI:122402

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