2. Gene
  3. Lonp1 - lon peptidase 1, mitochondrial Gene

Lonp1 - lon peptidase 1, mitochondrial Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LON; Prss15; 1200017E13Rik

Gene ID: 74142 | Gene type: protein coding

About Lonp1

Summary

Enables ATP hydrolysis activity; ATP-dependent peptidase activity; and DNA binding activity. Acts upstream of or within proteolysis. Located in mitochondrion. Is expressed in several structures, including adrenal medulla; alimentary system; genitourinary system; liver; and lung. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

Lonp1 Products(1)

mRNA Protein Name
NM_028782.2 NP_083058.2 lon protease homolog, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
12657466 MGI
enables ATP-dependent peptidase activity IDA
IDA: Inferred from direct assay
12657466 MGI
enables PH domain binding IPI
IPI: Inferred from physical interaction
9813005 MGI
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
9813005 MGI
NOT enables mitochondrial promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12657466 MGI
enables mitochondrial promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12657466 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
12657466 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
9813005 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
12657466 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
9813005 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12657466 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lon protease homolog, mitochondrial

LONP

lon protease-like protein

mitochondrial ATP-dependent protease Lon

protease, serine, 15

serine protease 15

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153034 LONP1-IN-2 Inhibitor 99.74% Unkown
HY-RS07734 LONP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-158412 BT317 99.81% Unkown
HY-N7196 Myrtucommulone A Inhibitor / Unkown
HY-RS18289 Lonp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24767 Lonp1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lonp1 NCBI NCBI:9361