2. Gene
  3. Ndufv2 - NADH:ubiquinone oxidoreductase core subunit V2 Gene

Ndufv2 - NADH:ubiquinone oxidoreductase core subunit V2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2900010C23Rik

Gene ID: 72900 | Gene type: protein coding

About Ndufv2

Summary

This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Ndufv2 Products(2)

mRNA Protein Name
NM_001278415.1 NP_001265344.1 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 2
NM_028388.3 NP_082664.1 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NADH dehydrogenase (ubiquinone) activity IDA
IDA: Inferred from direct assay
29915388 MGI
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial electron transport, NADH to ubiquinone IDA
IDA: Inferred from direct assay
29915388 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
26644517 MGI
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
29915388 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

NADH dehydrogenase (ubiquinone) flavoprotein 2

NADH-ubiquinone oxidoreductase 24 kDa subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09166 NDUFV2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21164 Ndufv2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27680 Ndufv2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufv2 NCBI NCBI:4729