Map3k13 - mitogen-activated protein kinase kinase kinase 13 Gene

Mus musculus

Also known as LZK; C130026N12Rik

Gene ID: 71751 | Gene type: protein coding

About Map3k13

Summary

Predicted to enable several functions, including IkappaB kinase complex binding activity; JUN kinase kinase kinase activity; and protein homodimerization activity. Involved in several processes, including positive regulation of JUN kinase activity; positive regulation of branching morphogenesis of a nerve; and positive regulation of cell projection organization. Predicted to be located in membrane. Is expressed in diencephalon lateral wall mantle layer; dorsal grey horn; late tubule; midbrain mantle layer; and ureter. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Apr 2022]

Map3k13 Products(1)

mRNA	Protein	Name
NM_172821.3	NP_766409.2	mitogen-activated protein kinase kinase kinase 13

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of neuron maturation	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of neuron projection arborization	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 13

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170595	PROTAC LZK-IN-1		/	Unkown
HY-RS08050	MAP3K13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21245	Map3k13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27762	Map3k13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k13	NCBI	NCBI:9175

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