2. Gene
  3. Acy3 - aspartoacylase (aminoacylase) 3 Gene

Acy3 - aspartoacylase (aminoacylase) 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AA3; AAIII; Acy-3; HCBP1; 0610006H10Rik

Gene ID: 71670 | Gene type: protein coding

About Acy3

Summary

This gene encodes a member of the aminoacylase family of Enzymes. This enzyme specifically deacetylates N-acetyl aromatic Amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Acy3 Products(4)

mRNA Protein Name
NM_001302479.1 NP_001289408.1 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1
NM_001302480.1 NP_001289409.1 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1
NM_001302481.1 NP_001289410.1 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1
NM_001302482.1 NP_001289411.1 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aminoacylase activity IDA
IDA: Inferred from direct assay
14656720 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
14656720 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
17434493 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23010594 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14656720 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14656720 MGI
located in membrane IDA
IDA: Inferred from direct assay
14656720 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

acylase III

aminoacylase III

aminoacylase-3

aspartoacylase-2

hepatitis C virus core-binding protein 1

Acy3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Acy3 Q91XE4 Acy3 Mus musculus Q91XE4
Protease Assay
23010594
Intra
Acy3 Q91XE4 Acy3 Mus musculus Q91XE4
GMS
17434493
Intra
Acy3 Q91XE4 Acy3 Mus musculus Q91XE4
X-Ray Diffraction
20921362
Intra
Acy3 Q91XE4 Acy3 Mus musculus Q91XE4
EM
17434493
Intra
Acy3 Q91XE4 polg_hcv1 Hepatitis C virus P26664
Protease Assay
23010594
Intra
Acy3 Q91XE4 polg_hcv1 Hepatitis C virus P26664
SPR
23010594
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-NP042 Protein A-Cy3 / Unkown
HY-RS00255 ACY3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19115 Acy3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25605 Acy3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acy3 NCBI NCBI:91703