2. Gene
  3. Optn - optineurin Gene

Optn - optineurin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NRP; FIP2; HYPL; 4930441O07Rik

Gene ID: 71648 | Gene type: protein coding

About Optn

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular protein localization and negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022]

Optn Products(2)

mRNA Protein Name
NM_001356487.1 NP_001343416.1 optineurin
NM_181848.5 NP_862896.1 optineurin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
17702576 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15607428 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
17702576 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
15607428 MGI
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15607428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

optineurin

TFIIIA-INTP

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-165298 DGY-09-192 / Unkown
HY-RS09809 OPTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18146 Optn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24621 Optn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Optn NCBI NCBI:10133