2. Gene
  3. Draxin - dorsal inhibitory axon guidance protein Gene

Draxin - dorsal inhibitory axon guidance protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as neucrin; 2610109H07Rik

Gene ID: 70433 | Gene type: protein coding

About Draxin

Summary

Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Located in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; future brain; neural retina; and vibrissa. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein). [provided by Alliance of Genome Resources, Apr 2022]

Draxin Products(1)

mRNA Protein Name
NM_027426.3 NP_081702.2 draxin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19857465 MGI
Biological Process GO Annotation Evidence Reference Source
involved in anterior commissure morphogenesis IMP
IMP: Inferred from mutant phenotype
23206892 MGI
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
19150847 MGI
involved in commissural neuron differentiation in spinal cord IMP
IMP: Inferred from mutant phenotype
19150847 MGI
involved in dorsal spinal cord development IMP
IMP: Inferred from mutant phenotype
19150847 MGI
involved in forebrain development IMP
IMP: Inferred from mutant phenotype
19150847 MGI
acts upstream of hippocampal neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19808066 MGI
acts upstream of or within negative regulation of axon extension IDA
IDA: Inferred from direct assay
20621059 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19857465 MGI
acts upstream of or within negative regulation of hippocampal neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19808066 MGI
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
23206892 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19808066 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular region IDA
IDA: Inferred from direct assay
20621059 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

draxin

dorsal repulsive axon guidance protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03990 DRAXIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21118 Draxin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27637 Draxin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Draxin NCBI NCBI:374946