Cox10 - heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 Gene

Mus musculus

Also known as 2410004F01Rik

Gene ID: 70383 | Gene type: protein coding

About Cox10

Summary

Predicted to enable farnesyltranstransferase activity. Acts upstream of or within several processes, including cytochrome complex assembly; heme A biosynthetic process; and mitochondrial fission. Located in mitochondrion. Is expressed in alimentary system; nervous system; and respiratory system. Used to study Parkinson's disease; cytochrome-c oxidase deficiency disease; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2022]

Cox10 Products(1)

mRNA	Protein	Name
NM_178379.3	NP_848466.1	protoheme IX farnesyltransferase, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protoheme IX farnesyltransferase activity	IMP IMP: Inferred from mutant phenotype	16782876	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aerobic respiration	IMP IMP: Inferred from mutant phenotype	16782876	MGI
acts upstream of or within copper ion homeostasis	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within cytochrome complex assembly	IDA IDA: Inferred from direct assay	16103131	MGI
acts upstream of or within heme A biosynthetic process	IDA IDA: Inferred from direct assay	16103131	MGI
involved in heme A biosynthetic process	IGI IGI: Inferred from genetic interaction	12928484	MGI
acts upstream of or within heme A biosynthetic process	IMP IMP: Inferred from mutant phenotype	16782876	MGI
involved in heme O biosynthetic process	IGI IGI: Inferred from genetic interaction	12928484	MGI
acts upstream of or within leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within mitochondrial fission	IMP IMP: Inferred from mutant phenotype	16103131	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	16782876	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	36301669	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial matrix	IDA IDA: Inferred from direct assay	16103131	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	16103131	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protoheme IX farnesyltransferase, mitochondrial

COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase	cytochrome c oxidase assembly protein 10
heme O synthase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03056	COX10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20891	Cox10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27408	Cox10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cox10	NCBI	NCBI:1352

Name
Email *

	Sorry, but the email address you supplied was invalid.