Znhit1 - zinc finger, HIT domain containing 1 Gene

Mus musculus

Also known as ZNFN4A1; 2700001K05Rik

Gene ID: 70103 | Gene type: protein coding

About Znhit1

Summary

Enables chromatin binding activity and histone deacetylase binding activity. Acts upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleus. Orthologous to human ZNHIT1 (zinc finger HIT-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Znhit1 Products(3)

mRNA	Protein	Name
NM_001310747.1	NP_001297676.1	zinc finger HIT domain-containing protein 1 isoform 2
NM_001310748.1	NP_001297677.1	zinc finger HIT domain-containing protein 1 isoform 3
NM_027318.4	NP_081594.1	zinc finger HIT domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19501046	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	19501046	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	29138493	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	35167494	MGI
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	29138493	MGI
involved in heart process	IMP IMP: Inferred from mutant phenotype	35167494	MGI
involved in hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	32694618	MGI
involved in intestinal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	30842416	MGI
acts upstream of or within negative regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	19501046	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19501046	MGI
involved in positive regulation of lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	29138493	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	29138493	MGI
acts upstream of or within regulation of T cell proliferation	IDA IDA: Inferred from direct assay	19501046	MGI
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	30842416	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19501046	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger HIT domain-containing protein 1

p18 Hamlet

zinc finger protein, subfamily 4A (HIT domain containing), member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16181	ZNHIT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21222	Znhit1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27738	Znhit1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Znhit1	NCBI	NCBI:10467

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