Wnk4 - WNK lysine deficient protein kinase 4 Gene

Mus musculus

Also known as Pha2b; Prkwnk4; 2010002J11Rik

Gene ID: 69847 | Gene type: protein coding

About Wnk4

Summary

Predicted to enable Chloride Channel Inhibitor activity; Potassium Channel Inhibitor activity; and protein serine/threonine kinase activity. Involved in ion transport. Acts upstream of or within chloride transport; negative regulation of pancreatic juice secretion; and protein localization. Located in bicellular tight junction and cytoplasm. Is expressed in several structures, including alimentary system; metanephros; metatarsal bone; sensory organ; and turbinate bone primordium. Used to study Gitelman syndrome and pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Wnk4 Products(1)

mRNA	Protein	Name
NM_175638.3	NP_783569.1	serine/threonine-protein kinase WNK4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride ion binding	IMP IMP: Inferred from mutant phenotype	30765526	MGI
enables ion channel inhibitor activity	IDA IDA: Inferred from direct assay	14608358	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17360471	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	21486947	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22114204	MGI
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	28096417	MGI
involved in aldosterone secretion	IMP IMP: Inferred from mutant phenotype	22550170	MGI
involved in calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	31496133	MGI
involved in cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	31496133	MGI
acts upstream of or within chloride transport	IDA IDA: Inferred from direct assay	14769928	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	28743496	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	22114204	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	31786261	MGI
involved in intracellular chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	30765526	MGI
involved in macrophage activation	IMP IMP: Inferred from mutant phenotype	31786261	MGI
involved in monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	23576762	MGI
acts upstream of or within negative regulation of pancreatic juice secretion	IMP IMP: Inferred from mutant phenotype	21317537	MGI
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	30765526	MGI
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17673510	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	28365586	MGI
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	12515852	MGI
involved in protein phosphorylation	IGI IGI: Inferred from genetic interaction	28743496	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22114204	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16964266	MGI
involved in regulation of potassium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	16964266	MGI
involved in regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	29921588	MGI
involved in renal sodium ion absorption	IMP IMP: Inferred from mutant phenotype	16964266	MGI
involved in renal sodium ion transport	IDA IDA: Inferred from direct assay	14608358	MGI
involved in response to dietary excess	IMP IMP: Inferred from mutant phenotype	22550170	MGI
involved in response to xenobiotic stimulus	IGI IGI: Inferred from genetic interaction	24039833	MGI
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	21486947	MGI
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24655003	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	11498583	MGI
is active in cell body	IMP IMP: Inferred from mutant phenotype	31736353	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14769928	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	25113964	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase WNK4

protein kinase with no lysine 4

protein kinase, lysine deficient 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100626	WNK463	Inhibitor	99.75%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnk4	NCBI	NCBI:65266

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