Gmppa - GDP-mannose pyrophosphorylase A Gene

Mus musculus

Also known as 1810012N01Rik

Gene ID: 69080 | Gene type: protein coding

About Gmppa

Summary

Predicted to enable nucleotidyltransferase activity. Predicted to be involved in biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and gonad. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Apr 2022]

Gmppa Products(4)

mRNA	Protein	Name
NM_001357169.1	NP_001344098.1	mannose-1-phosphate guanyltransferase alpha isoform 1
NM_001357170.1	NP_001344099.1	mannose-1-phosphate guanyltransferase alpha isoform 1
NM_001357171.1	NP_001344100.1	mannose-1-phosphate guanyltransferase alpha isoform 2
NM_133708.4	NP_598469.1	mannose-1-phosphate guanyltransferase alpha isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within GDP-mannose biosynthetic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within GDP-mannose metabolic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within glycoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within muscle organ morphogenesis	IMP IMP: Inferred from mutant phenotype	33755596	MGI
involved in negative regulation of biosynthetic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
involved in negative regulation of nucleobase-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
involved in negative regulation of phosphate metabolic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
involved in negative regulation of small molecule metabolic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within protein glycosylation	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within skeletal muscle organ development	IMP IMP: Inferred from mutant phenotype	33755596	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	33755596	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mannose-1-phosphate guanyltransferase alpha

GTP-mannose-1-phosphate guanylyltransferase alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05524	GMPPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20937	Gmppa Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27454	Gmppa Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gmppa	NCBI	NCBI:29926

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