2. Gene
  3. Eif4a3 - eukaryotic translation initiation factor 4A3 Gene

Eif4a3 - eukaryotic translation initiation factor 4A3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as eIF4A-III

Gene ID: 688288 | Gene type: protein coding

About Eif4a3

Summary

Enables RNA binding activity; ribonucleoprotein complex binding activity; and translation regulator activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; and regulation of translation. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Part of ribonucleoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Apr 2022]

Eif4a3 Products(1)

mRNA Protein Name
NM_001100158.2 NP_001093628.1 eukaryotic initiation factor 4A-III
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
21685449 RGD
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
17632064 RGD
enables selenocysteine insertion sequence binding IDA
IDA: Inferred from direct assay
21685449 RGD
Biological Process GO Annotation Evidence Reference Source
involved in associative learning IEP
IEP: Inferred from expression pattern
22982623 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
17632064 RGD
involved in cellular response to selenite ion IEP
IEP: Inferred from expression pattern
19716792 RGD
involved in exploration behavior IEP
IEP: Inferred from expression pattern
22982623 RGD
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17632064 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17632064 RGD
involved in negative regulation of selenocysteine incorporation IDA
IDA: Inferred from direct assay
19716792 RGD
involved in regulation of translation at postsynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
17632064 RGD
involved in regulation of translation at postsynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
17632064 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17632064 RGD
Cellular Component GO Annotation Evidence Reference Source
located in dendrite IDA
IDA: Inferred from direct assay
17632064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17632064 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17632064 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17632064 RGD
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17632064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic initiation factor 4A-III

ATP-dependent RNA helicase DDX48

ATP-dependent RNA helicase eIF4A-3

DEAD box protein 48

eIF-4A-III

Related Agents

Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101785 eIF4A3-IN-2 Inhibitor 99.70% Unkown
HY-101513 eIF4A3-IN-1 Inhibitor 99.96% Unkown
HY-33838 eIF4A3-IN-8 Inhibitor 99.98% Unkown
HY-148446 eIF4A3-IN-12 Inhibitor 99.70% Unkown
HY-148450 eIF4A3-IN-16 Inhibitor 98.37% Unkown
HY-43913 (R)-eIF4A3-IN-2 ≥95.0% Unkown
HY-148452 eIF4A3-IN-18 Inhibitor 99.58% Unkown
HY-139872 eIF4A3-IN-4 Inhibitor / Unkown
HY-145309 eIF4E-IN-3 Inhibitor / Unkown
HY-148443 eIF4A3-IN-9 Inhibitor 99.71% Unkown
HY-148444 eIF4A3-IN-10 Inhibitor 97.87% Unkown
HY-148445 eIF4A3-IN-11 Inhibitor 99.24% Unkown
HY-148447 eIF4A3-IN-13 Inhibitor 99.92% Unkown
HY-148448 eIF4A3-IN-14 Inhibitor 99.81% Unkown
HY-148449 eIF4A3-IN-15 Inhibitor / Unkown
HY-148451 eIF4A3-IN-17 Inhibitor 99.56% Unkown
HY-145359 eIF4A3-IN-5 Inhibitor / Unkown
HY-145360 eIF4A3-IN-6 Inhibitor / Unkown
HY-145361 eIF4A3-IN-7 Inhibitor / Unkown
HY-RS04272 EIF4A3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04279 EIF4EBP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04283 EIF4G3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17850 Eif4a3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24318 Eif4a3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4a3 NCBI NCBI:9775