Eml1 - echinoderm microtubule associated protein like 1 Gene

Mus musculus

Also known as EMAP; heco; ELP79; EMAPL; EMAP-1; 1110008N23Rik; A930030P13Rik

Gene ID: 68519 | Gene type: protein coding

About Eml1

Summary

Enables microtubule binding activity. Involved in brain development; mitotic spindle organization; and neuroblast proliferation. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytosol. Colocalizes with mitotic spindle midzone and mitotic spindle pole. Is expressed in Sertoli cell; liver; lung; nervous system; and retina. Used to study congenital nervous system abnormality and subcortical band heterotopia. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1). [provided by Alliance of Genome Resources, Apr 2022]

Eml1 Products(11)

mRNA	Protein	Name
NM_001043335.1	NP_001036800.1	echinoderm microtubule-associated protein-like 1 isoform 1
NM_001043336.2	NP_001036801.1	echinoderm microtubule-associated protein-like 1 isoform 2
NM_001286346.1	NP_001273275.1	echinoderm microtubule-associated protein-like 1 isoform 3
NM_001286347.1	NP_001273276.1	echinoderm microtubule-associated protein-like 1 isoform 4
NM_001364193.1	NP_001351122.1	echinoderm microtubule-associated protein-like 1 isoform 5
NM_001364194.1	NP_001351123.1	echinoderm microtubule-associated protein-like 1 isoform 6
NM_001364195.1	NP_001351124.1	echinoderm microtubule-associated protein-like 1 isoform 7
NM_001364196.1	NP_001351125.1	echinoderm microtubule-associated protein-like 1 isoform 4
NM_001364197.1	NP_001351126.1	echinoderm microtubule-associated protein-like 1 isoform 2
NM_001364198.1	NP_001351127.1	echinoderm microtubule-associated protein-like 1 isoform 8
NM_001364199.1	NP_001351128.1	echinoderm microtubule-associated protein-like 1 isoform 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	24859200	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	24859200	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	24029230	MGI
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24859200	MGI
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	24859200	MGI
involved in neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	24859200	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	24859200	MGI
colocalizes with mitotic spindle midzone	IMP IMP: Inferred from mutant phenotype	24859200	MGI
colocalizes with mitotic spindle pole	IMP IMP: Inferred from mutant phenotype	24859200	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

echinoderm microtubule-associated protein-like 1

echinoderm microtubule associated protein-like protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04353	EML1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18238	Eml1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24717	Eml1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eml1	NCBI	NCBI:2009

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