Pomgnt1 - protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase Gene

Mus musculus

Also known as 0610016I07Rik; 4930467B06Rik

Gene ID: 68273 | Gene type: protein coding

About Pomgnt1

Summary

Predicted to enable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and respiratory system. Used to study Walker-Warburg syndrome and muscular dystrophy-dystroglycanopathy. Human ortholog(s) of this gene implicated in lissencephaly; muscular dystrophy (multiple); and retinitis pigmentosa. Orthologous to human POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)). [provided by Alliance of Genome Resources, Apr 2022]

Pomgnt1 Products(3)

mRNA	Protein	Name
NM_001290658.1	NP_001277587.1	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 3
NM_026651.2	NP_080927.1	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 1
NM_029786.2	NP_084062.2	protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within basement membrane organization	IMP IMP: Inferred from mutant phenotype	21970971	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	26306834	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	21970971	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	21129441	MGI
acts upstream of or within localization of cell	IMP IMP: Inferred from mutant phenotype	26306834	MGI
acts upstream of or within myelination	IMP IMP: Inferred from mutant phenotype	32453729	MGI
acts upstream of or within protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	16458488	MGI
acts upstream of or within protein O-linked mannosylation	IMP IMP: Inferred from mutant phenotype	21460210	MGI
acts upstream of or within protein glycosylation	IMP IMP: Inferred from mutant phenotype	22728091	MGI
acts upstream of or within protein modification process	IMP IMP: Inferred from mutant phenotype	22270369	MGI
acts upstream of or within reactive gliosis	IMP IMP: Inferred from mutant phenotype	21970971	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	32453729	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

O-mannosyl N-acetylglucosaminyltransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10866	POMGNT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19548	Pomgnt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26044	Pomgnt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pomgnt1	NCBI	NCBI:55624

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