Wls - wntless WNT ligand secretion mediator Gene

Mus musculus

Also known as EVI; Gpr177; 5031439A09Rik

Gene ID: 68151 | Gene type: protein coding

About Wls

Summary

Enables Wnt-protein binding activity. Involved in several processes, including animal organ development; mesoderm formation; and positive regulation of canonical Wnt signaling pathway. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and skin. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Apr 2022]

Wls Products(3)

mRNA	Protein	Name
NM_001356349.1	NP_001343278.1	protein wntless homolog isoform 2 precursor
NM_001356350.1	NP_001343279.1	protein wntless homolog isoform 1
NM_026582.5	NP_080858.3	protein wntless homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	19841259	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19841259	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt protein secretion	IDA IDA: Inferred from direct assay	33324648	MGI
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19841259	MGI
involved in anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	19841259	MGI
involved in cementum mineralization	IGI IGI: Inferred from genetic interaction	31059863	MGI
involved in exocrine pancreas development	IMP IMP: Inferred from mutant phenotype	20614471	MGI
involved in hindbrain development	IMP IMP: Inferred from mutant phenotype	20614471	MGI
involved in mesoderm formation	IMP IMP: Inferred from mutant phenotype	19841259	MGI
involved in midbrain development	IMP IMP: Inferred from mutant phenotype	20614471	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20614471	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19841259	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	19841259	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	33324648	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	33324648	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein wntless homolog

G protein-coupled receptor 177	integral membrane protein GPR177
protein evenness interrupted homolog	wntless homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS15822	WLS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22087	Wls Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28607	Wls Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wls	NCBI	NCBI:79971

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