2. Gene
  3. Atp2b1 - ATPase, Ca++ transporting, plasma membrane 1 Gene

Atp2b1 - ATPase, Ca++ transporting, plasma membrane 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pmca1; 2810442I22Rik; E130111D10Rik

Gene ID: 67972 | Gene type: protein coding

About Atp2b1

Summary

Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; positive regulation of bone mineralization; and regulation of vascular associated smooth muscle contraction. Located in basolateral plasma membrane and immunological synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b1 Products(5)

mRNA Protein Name
NM_001359506.1 NP_001346435.1 plasma membrane calcium-transporting ATPase 1 isoform 1
NM_001359507.1 NP_001346436.1 plasma membrane calcium-transporting ATPase 1 isoform 3
NM_001359508.1 NP_001346437.1 plasma membrane calcium-transporting ATPase 1 isoform 3
NM_001359509.1 NP_001346438.1 plasma membrane calcium-transporting ATPase 1 isoform 4
NM_026482.2 NP_080758.1 plasma membrane calcium-transporting ATPase 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16352659 MGI
Biological Process GO Annotation Evidence Reference Source
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
16956963 MGI
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
28827723 MGI
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22311909 MGI
involved in positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
26392310 MGI
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
26392310 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
22311909 MGI
involved in regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24805951 MGI
involved in regulation of vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
24805951 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
23460639 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19233278 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
28827723 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
19233278 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19233278 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
30862855 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
30862855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma membrane calcium-transporting ATPase 1

plasma membrane calcium ATPase

plasma membrane calcium pump

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01194 ATP2B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20524 Atp2b1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27033 Atp2b1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2b1 NCBI NCBI:490