Rbpj - recombination signal binding protein for immunoglobulin kappa J region Gene

Rattus norvegicus

Gene ID: 679028 | Gene type: protein coding

About Rbpj

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of smooth muscle cell apoptotic process; negative regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in nucleus. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]

Rbpj Products(1)

mRNA	Protein	Name
NM_001106631.2	NP_001100101.1	recombining binding protein suppressor of hairless

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11997524	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	12145413	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15247148	RGD
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	15247148	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9790494	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15247148	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-DNA complex	IDA IDA: Inferred from direct assay	10773077	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11997524	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

recombining binding protein suppressor of hairless

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137471	RBPJ Inhibitor-1	Inhibitor	99.87%	Unkown
HY-RS11772	RBPJ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17271	Rbpj Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23725	Rbpj Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbpj	NCBI	NCBI:3516

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