Plxnd1 - plexin D1 Gene

Mus musculus

Also known as b2b553Clo; b2b1863Clo; 6230425C21Rik

Gene ID: 67784 | Gene type: protein coding

About Plxnd1

Summary

Enables semaphorin receptor activity. Involved in several processes, including endothelial cell migration; semaphorin-plexin signaling pathway; and synapse assembly. Acts upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and positive regulation of protein binding activity. Is integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; liver; nervous system; and spleen. Used to study DiGeorge syndrome. Orthologous to human PLXND1 (plexin D1). [provided by Alliance of Genome Resources, Apr 2022]

Plxnd1 Products(1)

mRNA	Protein	Name
NM_026376.4	NP_080652.2	plexin-D1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15239958	MGI
enables semaphorin receptor activity	IDA IDA: Inferred from direct assay	17318185	MGI
enables semaphorin receptor activity	IMP IMP: Inferred from mutant phenotype	25985275	MGI
enables semaphorin receptor activity	IPI IPI: Inferred from physical interaction	15239958	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	18992737	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15239958	MGI
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching	IDA IDA: Inferred from direct assay	17626059	MGI
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18992737	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	25985275	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	23918385	MGI
acts upstream of or within positive regulation of protein binding	IDA IDA: Inferred from direct assay	15239958	MGI
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17318185	MGI
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17318185	MGI
acts upstream of or within semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	15239958	MGI
involved in semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	25985275	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	17318185	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	22179111	MGI
involved in synaptic target recognition	IDA IDA: Inferred from direct assay	22179111	MGI
involved in synaptic target recognition	IMP IMP: Inferred from mutant phenotype	22179111	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	25985275	MGI
located in cell body	IDA IDA: Inferred from direct assay	25985275	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22179111	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22179111	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17318185	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plexin-D1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10756	PLXND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20190	Plxnd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26694	Plxnd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plxnd1	NCBI	NCBI:23129

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