Peli1 - pellino 1 Gene

Mus musculus

Also known as D11Ertd676e; 2810468L03Rik; A930031K15Rik

Gene ID: 67245 | Gene type: protein coding

About Peli1

Summary

Enables ubiquitin protein Ligase activity. Involved in negative regulation of necroptotic process. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of lymphocyte proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human PELI1 (pellino E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Peli1 Products(1)

mRNA	Protein	Name
NM_023324.2	NP_075813.2	E3 ubiquitin-protein ligase pellino homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19734906	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19734906	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	21874024	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell activation	IMP IMP: Inferred from mutant phenotype	21874024	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	21874024	MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21874024	MGI
acts upstream of or within negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	21874024	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	21874024	MGI
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	29883609	MGI
acts upstream of or within positive regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	21874024	MGI
acts upstream of or within protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	21874024	MGI
acts upstream of or within response to dsRNA	IMP IMP: Inferred from mutant phenotype	19734906	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19734906	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	21874024	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase pellino homolog 1

RING-type E3 ubiquitin transferase pellino homolog 1

protein pellino homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157435	PELI1-IN-1	Inhibitor	98.14%	Unkown
HY-RS10320	PELI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18832	Peli1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25324	Peli1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Peli1	NCBI	NCBI:57162

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