2. Gene
  3. Smarca2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Gene

Smarca2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as brm; Snf2l2; brahma; SNF2alpha; 2610209L14Rik

Gene ID: 67155 | Gene type: protein coding

About Smarca2

Summary

Predicted to enable several functions, including chromatin binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Acts upstream of or within aortic smooth muscle cell differentiation; hematopoietic stem cell homeostasis; and negative regulation of cell population proliferation. Located in nucleus. Part of nBAF complex and npBAF complex. Is expressed in several structures, including cerebral cortex; early conceptus; genitourinary system; heart; and vitelline artery. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smarca2 Products(10)

mRNA Protein Name
NM_001347439.2 NP_001334368.1 probable global transcription activator SNF2L2 isoform 3 precursor
NM_001405130.1 NP_001392059.1 probable global transcription activator SNF2L2 isoform 1
NM_001405131.1 NP_001392060.1 probable global transcription activator SNF2L2 isoform 1
NM_001405132.1 NP_001392061.1 probable global transcription activator SNF2L2 isoform 1
NM_001405133.1 NP_001392062.1 probable global transcription activator SNF2L2 isoform 4
NM_001405134.1 NP_001392063.1 probable global transcription activator SNF2L2 isoform 4
NM_001405135.1 NP_001392064.1 probable global transcription activator SNF2L2 isoform 4
NM_001405136.1 NP_001392065.1 probable global transcription activator SNF2L2 isoform 4
NM_011416.3 NP_035546.2 probable global transcription activator SNF2L2 isoform 1
NM_026003.3 NP_080279.1 probable global transcription activator SNF2L2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12368262 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within aortic smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19342595 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
26880577 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
Cellular Component GO Annotation Evidence Reference Source
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
12368262 MGI
part of nBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
part of npBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9603422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable global transcription activator SNF2L2

ATP-dependent helicase SMARCA2

BAF190B

BRG1-associated factor 190B

SNF2-alpha

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

protein brahma homolog

subunit of the SWI/SNF chromatin remodeling complex

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-144835 Camibirstat Inhibitor 99.06% Phase 1
Pre-clinical Phase
Bioactive Molecules (187)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119374 BRM/BRG1 ATP Inhibitor-1 Inhibitor 99.72% Unkown
HY-145388 AU-15330 99.89% Unkown
HY-128359 ACBI1 99.92% Unkown
HY-12409 PFI-3 Inhibitor 99.63% Unkown
HY-151623 ACBI2 Inhibitor 99.76% Unkown
HY-144896 FHT-1015 Inhibitor 98.41% Unkown
HY-W382038 E3 ligase Ligand 32 99.95% Unkown
HY-163410 AU-24118 Degrader 99.10% Unkown
HY-145446 SGC-SMARCA-BRDVIII Inhibitor 99.84% Unkown
HY-149026 GNE-064 Inhibitor 99.65% Unkown
HY-125905 VH032-cyclopropane-F 99.92% Unkown
HY-153361 YD23 98.80% Unkown
HY-144897 FHT-1204 Inhibitor 99.81% Unkown
HY-149458 FHT-2344 Inhibitor 99.67% Unkown
HY-156568B SMD-3040 formate Degrader 99.78% Unkown
HY-43048 2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid ≥95.0% Unkown
HY-156568 SMD-3040 Degrader 99.91% Unkown
HY-44012A SMARCA-BD ligand 1 for PROTAC dihydrochloride 98.56% Unkown
HY-163926 SMARCA2/4-IN-2 99.27% Unkown
HY-44012 SMARCA-BD ligand 1 for PROTAC 99.07% Unkown
HY-44012B SMARCA-BD ligand 1 for PROTAC hydrochloride 99.23% Unkown
HY-156568A SMD-3040 TFA Degrader 99.90% Unkown
HY-148381 A947 Inducer / Unkown
HY-W063924 Bpin-Cyclohexene-C-COOEt ≥97.0% Unkown
HY-159607 PRT3789 Degrader / Unkown
HY-122573 Bromodomain inhibitor-13 Inhibitor / Unkown
HY-122645 SMARCA2-IN-4 Inhibitor / Unkown
HY-153424 PROTAC SMARCA2 degrader-1 / Unkown
HY-153425 PROTAC SMARCA2 degrader-2 / Unkown
HY-159449 PROTAC SMARCA2 degrader-5 Degrader / Unkown
HY-159450 PROTAC SMARCA2 degrader-6 / Unkown
HY-159451 PROTAC SMARCA2 degrader-7 Inhibitor / Unkown
HY-159452 PROTAC SMARCA2/4-degrader-1 / Unkown
HY-159453 PROTAC SMARCA2/4-degrader-2 / Unkown
HY-159454 PROTAC SMARCA2/4-degrader-3 / Unkown
HY-159455 PROTAC SMARCA2/4-degrader-4 Degrader / Unkown
HY-159456 PROTAC SMARCA2/4-degrader-5 Degrader / Unkown
HY-159457 PROTAC SMARCA2/4-degrader-6 Degrader / Unkown
HY-159458 PROTAC SMARCA2/4-degrader-7 / Unkown
HY-159459 PROTAC SMARCA2/4-degrader-32 / Unkown
HY-159460 PROTAC SMARCA2/4-degrader-8 Inhibitor / Unkown
HY-159461 PROTAC SMARCA2/4-degrader-9 Degrader / Unkown
HY-159462 PROTAC SMARCA2 degrader-10 / Unkown
HY-159538 COOEt-bicyclo[2.2.2]octane-CHO / Unkown
HY-159548 Cyclopropane-(S,R,S)-AHPC-CO-cyclohexene-Bpin / Unkown
HY-159550 (S,R,S)-AHPC-CO-cyclohexene-Bpin / Unkown
HY-159553 Ac-NH-(S,R,S)-AHPC / Unkown
HY-159558 (S,R,S)-AHPC-CO-cyclohexane-C-Ph-pyrimidine-diazabicyclo / Unkown
HY-159575 COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo / Unkown
HY-159592 Piperazine-Pyrimidine-Cyclohexane-COOEt / Unkown
HY-159593 Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo / Unkown
HY-159594 Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo / Unkown
HY-159677 E3 Ligase Ligand-linker Conjugate 115 / Unkown
HY-159678 4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate / Unkown
HY-159679 E3 Ligase Ligand-linker Conjugate 116 / Unkown
HY-159680 OMs-PEG2-NHAlloc-PEG2-Boc / Unkown
HY-159682 3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin / Unkown
HY-159683 E3 Ligase Ligand-linker Conjugate 117 / Unkown
HY-159683A E3 Ligase Ligand-linker Conjugate 119 / Unkown
HY-159684 3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin / Unkown
HY-159685 E3 Ligase Ligand-linker Conjugate 118 / Unkown
HY-161881 SMARCA2-IN-9 Inhibitor / Unkown
HY-161882 PROTAC SMARCA2 degrader-8 / Unkown
HY-161883 JP-2-249 Degrader / Unkown
HY-161884 SMARCA2/4-IN-1 Inhibitor / Unkown
HY-161885 SMARCA2-IN-6 Inhibitor / Unkown
HY-161886 SMARCA2-IN-7 Inhibitor / Unkown
HY-161887 SMARCA2-IN-8 Inhibitor / Unkown
HY-161888 DCSM06 Inhibitor / Unkown
HY-161889 DCSM06-05 Inhibitor / Unkown
HY-162245 PROTAC SMARCA2 degrader-3 Inhibitor / Unkown
HY-162739 SMARCA2-IN-1 Inhibitor / Unkown
HY-162740 SMARCA2-IN-2 Inhibitor / Unkown
HY-162741 PROTAC SMARCA2/4-degrader-33 / Unkown
HY-162742 PROTAC SMARCA2 degrader-16 / Unkown
HY-162743 PROTAC SMARCA2/4-degrader-29 Degrader / Unkown
HY-162744 PROTAC SMARCA2/4-degrader-31 Degrader / Unkown
HY-162745 SMARCA2 degrader-20 / Unkown
HY-162746 PROTAC SMARCA2 degrader-9 / Unkown
HY-162747 PROTAC SMARCA2 degrader-17 / Unkown
HY-162748 PROTAC SMARCA2/4-degrader-30 Degrader / Unkown
HY-162791 (1s,4s)-C1-Piperidine-C1-cyclohexane-C1 / Unkown
HY-162792 E3 Ligase Ligand-linker Conjugate 112 / Unkown
HY-162813 PROTAC SMARCA2/4-degrader-25 / Unkown
HY-162814 SMARCA2/4-ligand-3 / Unkown
HY-162815 PROTAC SMARCA2/4-degrader-26 / Unkown
HY-162834 PROTAC SMARCA2/4-degrader-27 Degrader / Unkown
HY-162835 PROTAC SMARCA2/4-degrader-28 Degrader / Unkown
HY-163864 PROTAC SMARCA2/4-degrader-11 / Unkown
HY-163865 PROTAC SMARCA2 degrader-13 / Unkown
HY-163866 PROTAC SMARCA2 degrader-14 / Unkown
HY-163867 PROTAC SMARCA2 degrader-15 / Unkown
HY-163868 PROTAC SMARCA2/4-degrader-15 Degrader / Unkown
HY-163869 PROTAC SMARCA2/4-degrader-16 / Unkown
HY-163870 PROTAC SMARCA2/4-degrader-17 Degrader / Unkown
HY-163871 PROTAC SMARCA2/4-degrader-18 Degrader / Unkown
HY-163872 PROTAC SMARCA2/4-degrader-10 Degrader / Unkown
HY-163873 PROTAC SMARCA2/4-degrader-20 Degrader / Unkown
HY-163874 PROTAC SMARCA2 degrader-12 / Unkown
HY-163875 PROTAC SMARCA2/4-degrader-22 / Unkown
HY-163876 PROTAC SMARCA2/4-degrader-23 / Unkown
HY-163877 PROTAC SMARCA2/4-degrader-19 Degrader / Unkown
HY-163932 (S,R,S)-AHPC-O-CF3 / Unkown
HY-163933 (S,R,S)-AHPC-CO-C-cyclohexane / Unkown
HY-163934 (S,R,S)-AHPC-phenylacetic acid / Unkown
HY-163935 (S,R,S)-AHPC-m-Tolylacetic acid / Unkown
HY-163936 (S,R,S)-AHPC-p-toluic acid / Unkown
HY-163937 (S,R,S)-AHPC-O-CF3 -CO-cyclohexane / Unkown
HY-163949 SMARCA2/4-IN-3 / Unkown
HY-163950 (S,R,S)-AHPC-O-CF3-CO-cyclohexene-Bpin / Unkown
HY-163951 (S,R,S)-AHPC-Ac / Unkown
HY-163952 (S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin / Unkown
HY-163953 (S,R,S)-AHPC-Ala / Unkown
HY-163954 (S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin / Unkown
HY-168215 YDR1 Degrader / Unkown
HY-168221 YD54 / Unkown
HY-168222 Thalidomide-PEG1-OTs / Unkown
HY-168223 Boc-Piperazine-2-F-Ph-CHO / Unkown
HY-168225 PROTAC SMARCA2/4-degrader-35 / Unkown
HY-168226 E3 ligase Ligand 34 / Unkown
HY-168228 E3 Ligase Ligand-linker Conjugate 123 / Unkown
HY-168229 PROTAC SMARCA2 degrader-27 Degrader / Unkown
HY-168230 SMARCA2 ligand-9 / Unkown
HY-168231 trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH / Unkown
HY-168232 E3 ligase Ligand 35 / Unkown
HY-168234 PROTAC SMARCA2 degrader-31 Inhibitor / Unkown
HY-168235 (S,R,S)-AHPC-Me-amide-C9-acid Degrader / Unkown
HY-168236 PROTAC SMARCA2 degrader-28 Degrader / Unkown
HY-168237 SMARCA2 ligand-10 / Unkown
HY-168238 (4-(3-Bromobenzyl)piperazin-1-yl)(piperidin-4-yl)methanone / Unkown
HY-168239 Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph / Unkown
HY-168246 PROTAC SMARCA2 degrader-29 Degrader / Unkown
HY-168257 PROTAC SMARCA2 degrader-30 Inhibitor / Unkown
HY-169269 PROTAC SMARCA2 degrader-18 Degrader / Unkown
HY-169270 PROTAC SMARCA2 degrader-19 Degrader / Unkown
HY-169271 PROTAC SMARCA2 degrader-20 Degrader / Unkown
HY-169272 PROTAC SMARCA2 degrader-21 Degrader / Unkown
HY-169273 PROTAC SMARCA2 degrader-22 Degrader / Unkown
HY-169274 PROTAC SMARCA2 degrader-23 Degrader / Unkown
HY-169275 PROTAC SMARCA2 degrader-24 Degrader / Unkown
HY-169276 PROTAC SMARCA2 degrader-25 / Unkown
HY-169278 PROTAC SMARCA2 degrader-26 Degrader / Unkown
HY-169279 PROTAC SMARCA2/4-degrader-34 Degrader / Unkown
HY-169280 PXR Ligand 2 / Unkown
HY-169487 SMARCA2 ligand-12 Inhibitor / Unkown
HY-169488 SMARCA2 ligand-12-3-methylazetidine Inhibitor / Unkown
HY-169490 SMARCA2 ligand-13 PYR-Pip-spiro[3.3]heptane-acid / Unkown
HY-170343 PROTAC SMARCA2 degrader-32 Degrader / Unkown
HY-170347 PROTAC SMARCA2/4 degrader-36 Degrader / Unkown
HY-170348 (S)-(S,R,S,R)-AHPC-Me-N3 / Unkown
HY-170349 SMARCA2 ligand-11 Ligand / Unkown
HY-170352 E3 Ligase Ligand-linker Conjugate 150 / Unkown
HY-170353 E3 ligase Ligand 46 / Unkown
HY-170354 SMARCA2/4-ligand-4 / Unkown
HY-170356 E3 Ligase Ligand-linker Conjugate 151 / Unkown
HY-170824 SMD-3236 Degrader / Unkown
HY-170826 SMARCA2 ligand-14 Ligand / Unkown
HY-170827 E3 Ligase Ligand-linker Conjugate 159 / Unkown
HY-170828 SMD-1087 Degrader / Unkown
HY-171765 SMARCA2/4-ligand-6 / Unkown
HY-171774 PBRM1/SMARCA2,4-ligand-1 / Unkown
HY-172117 Boc-methylglycine-C2-bromine / Unkown
HY-173333 PROTAC SMARCA2/4 degrader-38 / Unkown
HY-173351 G-6599 Degrader / Unkown
HY-174237 PBRM1/SMARCA2,4 binder-1 / Unkown
HY-400685 SMD-3040 intermediate-2 95.82% Unkown
HY-44824 SMARCA2 ligand-13 Inhibitor / Unkown
HY-RS13404 SMARCA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W560922 Piperazine-Ac-OMe / Unkown
HY-W890392 (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate / Unkown
HY-159472 SMARCA2/4-ligand-1 / Unkown
HY-159539 COOEt-spiro[3.3]heptane-CHO / Unkown
HY-159542 SMARCA2 ligand-6 / Unkown
HY-159543 (S,R,S)-AHPC-CO-Ph-Ph-CHO / Unkown
HY-159544 SMARCA2 ligand-7 / Unkown
HY-159545 SMARCA2/4-ligand-2 / Unkown
HY-159546 (S,R,S)-AHPC-Me-CO-cyclohexene-Bpin / Unkown
HY-159549 (S,R,S)-AHPC-CO-C-Cyclohexene-Bpin / Unkown
HY-159556 Dimethylformamide-(S,R,S)-AHPC / Unkown
HY-168227 trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc / Unkown
HY-168233 E3 Ligase Ligand-linker Conjugate 124 / Unkown
HY-169861 PROTAC SMARCA2/4 degrader-37 Degrader / Unkown
HY-172446 SMARCA2/4-ligand-5 / Unkown
HY-172738 E3 Ligase Ligand-linker Conjugate 175 / Unkown
HY-RS16570 Smarca2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23003 Smarca2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W874018 SMARCA2 ligand-8 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smarca2 NCBI NCBI:6595